Molecular Docking of Fragment Library and Triazoles against Protease Protein of Mycobacterium fortuitum

Abstract

Mycobacterium fortuitum is a nontuberculous species of the phylum Actinomycetota. M. fortuitum is an important human pathogenic NTM, which resists stress conditions inside macrophages by exploitation of virulence specific genes. A significant part of the host organism's infection is caused by biofilms. One of the biggest functional groups of proteins is the protease family. Proteases are enzymes that break down proteins into smaller peptides or individual amino acids. Since proteases are frequently secreted into the microbial environment, they make excellent markers for the detection of bacterial infections. Protease protein is one of the proteins that M. fortuitum upregulates during the biofilm growth phase.