Please use this identifier to cite or link to this item: http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9391
Title: High-throughput screening of natural compounds and inhibition of a major therapeutic target HsGSK-3β for Alzheimer’s disease using computational approaches
Authors: Shukla, Rohit
Singh, Tiratha Raj
Keywords: Alzheimer’s disease
Neurofibrillary tangles
Virtual screening
Molecular docking
Principal component analysis
Issue Date: 2021
Publisher: Jaypee University of Information Technology, Solan, H.P.
Abstract: Alzheimer’s disease is a leading neurodegenerative disease worldwide and is the 6th leading cause of death in the USA. AD is a very complex disease and the drugs available in the market cannot fully cure it. The glycogen synthase kinase 3 beta plays a major role in the hyperphosphorylation of tau protein which forms the neurofibrillary tangles which is a major hallmark of AD. In this study, we have used a series of computational approaches to find novel inhibitors against GSK-3β to reduce the TAU hyperphosphorylation
URI: http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9391
Appears in Collections:Journal Articles



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