Please use this identifier to cite or link to this item: http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9193
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dc.contributor.authorPatel, Sita Sharan-
dc.contributor.authorGupta, Sahil-
dc.contributor.authorUdayabanu, Malairaman-
dc.date.accessioned2023-01-14T04:56:11Z-
dc.date.available2023-01-14T04:56:11Z-
dc.date.issued2016-
dc.identifier.urihttp://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9193-
dc.description.abstractDiabetes mellitus has been associated with functional abnormalities in the hippocampus and performance of cognitive function. Urtica dioica (UD) has been used in the treatment of diabetes. In our previous report we observed that UD extract attenuate diabetes mediated associative and spatial memory dysfunction. The present study aimed to evaluate the effect of UD extract on mouse model of diabetes-induced recognition memory deficit and explore the possible mechanism behind it. Streptozotocin (STZ) (50 mg/kg, i.p. consecutively for 5 days) was used to induce diabetes followed by UD extract (50 mg/kg, oral) or rosiglitazone (ROSI) (5 mg/kg, oral) administration for 8 weeks. STZ induced diabetic mice showed significant decrease in hippocampal insulin signaling and translocation of glucose transporter type 4 (GLUT4) to neuronal membrane resulting in cognitive dysfunction and hypolocomotion. UD treatment effectively improved hippocampal insulin signaling, glucose tolerance and recognition memory performance in diabetic mice, which was comparable to ROSI. Further, diabetes mediated oxidative stress and inflammation was reversed by chronic UD or ROSI administration. UD leaves extract acts via insulin signaling pathway and might prove to be effective for the diabetes mediated central nervous system complicationsen_US
dc.language.isoenen_US
dc.publisherJaypee University of Information Technology, Solan, H.P.en_US
dc.subjectCognitionen_US
dc.subjectInsulin receptoren_US
dc.titleUrtica dioica modulates hippocampal insulin signaling and recognition memory deficit in streptozotocin induced diabetic miceen_US
dc.typeArticleen_US
Appears in Collections:Journal Articles



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