Model of Mitogen Activated Protein Kinases for Cell Survival/Death and its Equivalent Bio-circuit

Abstract

Cell proliferation, differentiation and programmed cell death (apoptosis) are tightly regulated in healthy tissues by a variety of external signals working via receptors that activate intracellular signal transduction pathways. Combining engineering analyses and mathematical modeling with intervention and detection methodologies at the molecular level will allow manipulation of intracellular signal transduction pathways and therefore rational control of functional processes central to medicine and biotechnology. We have made computational model for mitogen-activated protein kinase (MAPK), on the basis of that model we have made the truth tables, Boolean equations and than implement the equations using logic circuits and Bio-circuits showing cell survival and death.