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http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9028Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Thakur, Raman | - |
| dc.contributor.author | Shankar, Jata | - |
| dc.date.accessioned | 2023-01-09T05:42:35Z | - |
| dc.date.available | 2023-01-09T05:42:35Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.uri | http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9028 | - |
| dc.description.abstract | Pentraxin-3(PTX-3)proteinisanevolutionaryconservedproteinthatactsasasolublepattern-recognitionreceptorforpathogensandplaysimportantroleininnateimmuneresponse.Itrecognizesvariouspathogensbyinteractingwithextracellularmoietiessuchasglactomannanofconidia(Aspergillusfumigatus),lipopolysaccharideofPseudomonasaeruginosa,StreptococcuspneumoniaandSalmonellatyphimurium.Thus,PTX-3proteinhelpstoclearthesepathogensbyactivatingdownstreaminnateimmuneprocess.Inthisstudy,computationalmethodswereusedtoanalyzevariousnon-synonymoussinglenucleotidepolymorphisms(nsSNPs)inPTX-3gene.ThreedifferentdatabaseswereusedtoretrieveSNPdatasetsfollowedbysevendifferentinsilicoalgorithmstoscreennsSNPsinPTX-3gene.SequencehomologybasedapproachwasusedtoidentifynsSNPs.ConservationprofileofPTX-3proteinaminoacidresidueswerepredictedbyConSurfwebserver.Intotal,10high-risknsSNPswereidentifiedinpentraxin-domainofPTX-3gene.Outofthese10high-risknsSNPs,4werepresentintheconservedstructuralandfunctionalresiduesofthepentraxin-domain,hence,selectedforstructuralanalyses.Theresultsshowedalterationintheputativestructureofpentraxin-domain.Predictionofprotein–proteininteractionsanalysisshowedassociationofPTX-3proteinwithC1qcomponentofcomplementpathway.DifferentfunctionalandstructuralresiduesalongwithvariousputativephosphorylationsitesandevolutionaryrelationshipwerealsopredicteforPTX-3protein.ThisisthefirstextensivecomputationalanalysesofpentraxinproteinfamilywithnsSNPsandwillserveasavaluableresourceforfuturepopulatiobasedstudies. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Jaypee University of Information Technology, Solan, H.P. | en_US |
| dc.subject | PTX-3 | en_US |
| dc.subject | In silico | en_US |
| dc.subject | Aspergillusfumigatus | en_US |
| dc.subject | lipopolysaccharide | en_US |
| dc.title | InsilicoAnalysisRevealedHigh-riskSingleNucleotidePolymorphismsinHumanPentraxin-3GeneandtheirImpactonInnateImmuneResponseagainstMicrobialPathogens | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Journal Articles | |
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