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http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9012| Title: | CytokinesinduceeffectorT-helpercellsduringinvasiveaspergillosis;whatwehavelearnedaboutT-helpercells |
| Authors: | Thakur, Raman Anand, Rajesh Tiwari, Shraddha Singh, Agam Tiwary, Bhupendra N. Shankar, Jata |
| Keywords: | Cytokines Dendriti cells Aspergillus Antigen presenting cells |
| Issue Date: | 2015 |
| Publisher: | Jaypee University of Information Technology, Solan, H.P. |
| Abstract: | InvasiveaspergillosiscausedbyAspergillusspecies(Aspergillusfumigatus,A.flavus,andA.terreus)islife-threateninginfectionsinimmunocompromisedpatients.UnderstandingtheinnateandadaptiveimmuneresponseparticularlyT-helpercells(TH-cells)againsttheseAspergillusspeciesandhowthedifferentsub-setofTH-cellsareregulatedbydifferentiatingcytokinesatprimarytargetorgansitelikelung,kidneyandbrainisofgreatsignificancetohumanhealth.ThisreviewfocusesonpresentationofAspergillusthroughAntigenpresentingcells(APCs)tothenaiveCD4+T-cellsinthehost.Theproductionofdifferentiating/effectorcytokinesthatactivatefollowingTH-cells,e.g.,TH1,TH2,TH9,andTH17hasbeenreportedinassociationoraloneinallergicorinvasiveaspergillosis.Chemokines(CXCL1,CXCL2,CCL1,andCCL20)andtheirreceptorsassociatedtotheseTH-cellshavealsobeenobservedininvasiveaspergillosis.Thus,furtherstudyoftheseTH-cellsininvasiveaspergillosisandotherelementsofadaptiveimmuneresponsewithAspergillusspeciesarerequiredinordertohaveabetterundersandingofhostresponseforsaferandeffectivetherapeuticoutcome. |
| URI: | http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9012 |
| Appears in Collections: | Journal Articles |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Cytokines induce effector T-helper cells during invasive aspergillosis what we have learned about T-helper cells.pdf | 775.12 kB | Adobe PDF | View/Open |
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