Communication of Signals and Responses Leading To Cell Death Using Engineered Regulatory Networks

Abstract

This paper demonstrates the cell death/ apoptosis pathways considering three inputs Tumor Necrosis Factor (TNF), Epidermal Growth factor (EGF) and Insulin. Basically death pathway is a two process pathway: extrinsic pathway and intrinsic pathway. Later on pathways are converted into truth tables considering ‘1’ as cell survival and ‘0’ as cell death. The truth tables are implemented in VHDL using XILINX ISE, CMOS using SPICE and Fuzzy Logic using MATLAB. Out of three processes Fuzzy Logic is the best implementation in terms of reproducibly, computation time and ease in computation.