Design of Broad Specific Lead Molecules against Proteins Involved In Efflux Pump Mechanism in Mycobacterium Tuberculosis

Abstract

Tuberculosis, is a common, infectious disease caused by the bacteria Mycobacterium tuberculosis. TB kills around 1.7 million people every year despite the availability of effective chemotherapy for more than half a century. The remarkable capacity of this pathogen to escape the host immune system for decades and then to cause active tuberculosis disease, makes MTB a successful pathogen. Currently available anti-mycobacterial therapy has poor compliance due to requirement of prolonged treatment resulting in accelerated emergence of drug resistant strains. Bacterial efflux pump mechanism play a major role in development of drug resistance. While inhibitors can inactivate the efflux pumps and make the bacteria vulnerable to the drugs. So if inhibitors are taken along with drugs the disease could be effectively treated. So aim of this project is to design lead molecules for development of inhibitors against drug-resistant strains of TB and shortens the treatment period. A treatment that can eliminate TB in less time could interrupt the transmission of this deadly disease.