Study of the Physico-Chemical Properties of Vancomycin Hydrochloride for Applications in the Formulation Development

Abstract

The study of physico-chemical properties of vancomycin hydrochloride is an important parameter in the pre–formulation analysis of a drug. Pre-formulation study provides important information for formulation design or support the need for molecular modification. The main objective of pre-formulation is to develop a stable and an effective drug, with a safe dosage. Therefore properties like density, specific conductivity, surface tension, viscosity, velocity of sound and specific gravity are determined. Using these parameters further studies are carried out for the determination of critical micelle concentration (CMC). Other thermodynamic parameters are calculated from CMC like change in entropy, enthalpy and Gibb’s free energy which indicated that formation of micelles is a favourable and exothermic in nature. Along with this, thermo-acoustic parameters are also determined that revealed that electrostatic interactions were favourable at lower concentrations and hydrophobic at higher concentrations. All this study may aid in development of the topical formulation of vancomycin hydrochloride.