Uncovering Antigenic Property of Protein Through Mutation Finding in DNA Repair Sequences

Abstract

The body's immune system develops antibodies that recognize and bind to “antigenic sites”, which are regions found on a virus surface proteins. The distinct surface features of an antigen is its antigenic determinant. Antigenic molecules, normally "large" biological polymers, usually present surface features that can act as points of interaction for specific antibodies. Antigenic Sites show the statistically significant. For example in regards to influenza viruses, an antigenic site is the area on the protein spike protruding from their lipid bilayer that carries the receptor binding sites. This is supposed to trigger an immune response when your body detects these sites by binding antibodies to them. Each antibody is specifically produced by the immune system to match an antigen after cells in the immune system come into contact with it; this allows a precise identification of the antigen and the initiation of a tailored response. The triplet nature of the genetic code means that base changes within coding sequence can have several different outcomes. In this we did mutations so as to change in one DNA base pair that results in the substitution of one amino acid for another in the protein made by a gene. All the mutations and their impacts on ADNA repair systems have been checked and verified for their specific roles in various mechanisms involved.