Physico-Chemical Studies of Quercetin with Cationic Surfactant CTAB in Hydro-Ethanolic Solvent System

Abstract

Flavonoids are very well known for its use in pharmaceutical industry possessing various health benefits that can be utilised for tackling the problem of numerous health related diseases. Quercetin, a flavonoid possesses greater health benefits but its use is limited due to various insolubility and instability problems and thus, is taken into consideration. Thermodynamic and thermoacoustic properties of Quercetin at different concentration have been studied in interaction with CTAB surfactant in varied hydro-ethanolic concentrations at different temperatures. The conductivity of the overall system has been studied and further, it has been utilised to calculate Change in Enthalpy (ΔH), Entropy (ΔS) and Gibbs free Energy (ΔG) of micellization. The study revealed that though the interactions between Quercetin and CTAB are endothermic in nature, the reaction spontaneously proceeds in forward direction. Further, density and ultrasonic sound velocity parameters have been used to calculate the thermoacoustic parameters i.e. apparent molar volume and apparent adiabatic compressibility. Thermoacoustic properties revealed the dominance of hydrophobic interactions at higher surfactant concentration. The data has been found to be more favourable in hydro-ethanolic solution as compared to that of aqueous solution. Overall, the interactions are favourable for the system to be utilised for formulation development studies, drug development, medical administration, drug industry and pharmaceutical industries