Modeling and Simulation studies of DNA repair genes MLH1, MSH2, MSH6, PMS1, PMS2 with reference to HE4 gene

Abstract

The two most important components of our project are modeling and simulation of the genes involved in the endometrial and ovarian cancer. The bottom up approach was used starting from the data collection, followed by expanding the data by retrieving their interacting partners, thereby following the pathway targeting approach and using the gathered data to build the model, run the simulations so as to state the hypothesis which could be further validated in wet laboratory. The curves obtained after running the simulations provide the insight about the attaining of the steady state under the constraints of time and concentration for all the genes under study. This hypothesis depicts the behavior of the genes in unit time and unit concentration and how the behavior deviates from the normal behavior when the expression values and reaction rates are changed in order to achieve the steady state.