In Silico Screening of Putative Drug Molecules to Target MSI Pathway for Colorectal Cancer and HNPCC

Abstract

The findings that different molecular pathways are involved in colorectal cancer development have helped researchers build different models and understand how colorectal cancer initiates and progresses. However, the application of molecular markers on large scale populations is now facilitating the understanding of the peculiar role of these alterations on disease behavior, prognosis and response to treatments. • We predicted damage for 457 different CRC associated SNP’s out of which total 108 are found to be highly damaged. • Better understanding of mutations at various positions in genome