Computational Characterization of Nucleotide Excision Repair (Ner) Pathway in Skin Cancer

Abstract

The thesis of our project is divided into four major parts. The first part, or Chapter 1 is related to background study of the skin cancers, how and what kind of data was collected with respect to the rare forms of skin cancers, namely Xeroderma pigmentosum, Cockayne Syndrome and Trichothiodystrophy. The second part or Chapter 2, describes the design, development and implementation perspectives for making a database, i.e., we developed a Skin Cancer Knowledgebase which aims to be a sole information repository for the above mentioned diseases. Chapter 3, or the third part, is associated with biological/bio-computational analysis of the data we have collected and stored, and represented in our database. Lastly, Chapter 4 serves as conclusion of the complete project. The main aim of this project was to explore the problems underlying in the study of rarest forms of skin cancer, why these diseases have been considered as the hotspot for the research in skin cancers, and how our database and computational analysis is helpful in resolving this issue.