Applications of statistical and docking approach for the prediction of lead molecule against Isocitrate lyase, an enzyme involved in the persistence of Mycobacterium tuberculosis

Abstract

Tuberculosis (TB) is a disease caused by a bacterium called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, brain, etc. If it is not treated properly, TB can cause death. TB can also pass from a mother to her unborn child before and after birth. TB is more common in children and people with weak immune systems and people with HIV. Mycobacterium tuberculosis is a pathogen that hides in the macrophages of its host. Because macrophage is important for removing the infection, the interaction of pathogen and host cell reveals a continuous clash for control.