Computational Modeling of Cell Survival Using VHDL

Abstract

The model for cell survival has been implemented using Very High Speed Integrated Circuit Hardware Description Language (VHDL) (Xilinx Tool) taking three input signals: Tumor necrosis factor-α (TNF), Epidermal growth factor (EGF) and Insulin. Cell survival has been regulated by the interaction of five proteins viz P13K, TNFR1, EGFR, IRS and IKK in a network. In the absence of any one, in protein network leads to cell death. For the EGF input signal the proteins like MEK, ERK, AkT, Rac & JNK have been important for regulation of cell survival. Similarly for TNF and Insulin input signal proteins like NFκB, AkT, XIAP, JNK, MAP3K & MK2 and MEK, ERK, AkT, Rac, mTOR & JNK respectively have been important for regulation of cell survival.