Analysis of surfactant micelles and their interaction with antimicrobial drug itraconazole for potential pharmaceutical application

Abstract

Drug surfactant interaction have received an increased attention in the recent past because of widespread applications of surfactants in pharmaceutical field. The physiochemical interaction of drugs with surfactant micelles can be visualised as an approximation for their interactions with biological tissues at the molecular level is their ability to bind to membrane resulting into drug action. This thesis investigates the physico-chemical properties to obtain the critical micelle concentration (CMC) and thermodynamic properties i.e the values of ΔH°m, ΔG°m, ΔS°m of surfactants i.e anionic surfactant sodium dodecyl sulfate (SDS), cationic surfactant cetyl trim ethyl ammonium bromide (CTAB), non-ionic surfactant TWEEN 20 in presence of anti microbial drug i.e itraconazole, at different temperatures 25ºc, 30ºc and 35ºc. Further topical gel formulation have been formed and its physical & analytical evaluation (physical appearance &spreadability) studies with the help of optimum concentration of drug/surfactants have been evaluated.