Analysis of Interstitial Lung Diseases and Integrated Analysis Between Micro RNA and MRNA

Abstract

Interstitial lung diseases are a unique group of lung disorders that damage the tissues. The alveolar epithelium, base membrane, perivascular and pulmonary capillary endothelium are all affected by these lung disorders. These disorders happen due to degeneration or damage to the lungs which results in abnormal immune response in the organism. Generally, the body produces enough amounts of fiber bundle tissues to compensate the damage caused to various parts of lungs however in interstitial lung diseases, the repair of lung tissues does not happen properly causing the tissue around the air sacs to become swollen and scarred . Scarring of lung tissues makes the transport of oxygen in blood very difficult. Interstitial lung disease identifies a different group of diseases which show a lot of variation than obstructive pathway diseases. 2013 showed cases of 600,231 interstitial lung diseases globally resulting in 523,112 deaths. When we consider the fact that microRNAs in more amounts tends to change or affect the expression of a considerable part of genome and the complex biological pathway in which they function, we can understand that their deregulation has a significant repercussion on the proper functions and metabolism in an organism. An increasing number of groups of miRNAs are known to be involved in different interstitial lung diseases that have hugely enabled us to better understand their metabolic pathways and stages of maturation.