Drug Surfactant Interactions a physico chemical approach

Abstract

In the present study, sodium dodecyl sulfate (SDS) which is an anionic surfactant and antifungal drug Terbinafine HCl which is a derivative of ‘Azole’ family were used to study the thermodynamic parameters and acoustical parameters through thermo-acoustic methods. The critical micelle concentrations were studied at different concentrations of SDS (1 mmol dm-3- 14 mmol dm-3) at different temperatures (25°C- 40°C) with the difference of 5°C in various ethanol solutions- 10%, 20% and 30%. Comparative studies were also incorporated with the addition of turmeric as excipient and marketed formulation (THClm). Further thermodynamic parameters ΔH°m, ΔG°m and ΔS°m, viscosity coefficients A and B coefficients and the acoustical studies which involve density and sound velocity analysis using DSA (500) were also measured for all the systems to evaluate physico- chemical analysis of drug- surfactant interaction.