Development of database of genes involved in Gastric Cancer

Abstract

Carcinoma of the stomach is still the second most common cause of cancer death worldwide, although the incidence and mortality have fallen dramatically over the last 50 years in many regions. The incidence of gastric cancer varies in different parts of the world and among various ethnic groups. Despite advances in diagnosis and treatment, the 5-year survival rate of stomach cancer is only 20 per cent. There is no source available which integrates all the information of genes and miRNAs scattered in literature. So, we have done exhaustive research from published research articles and collected genes, and miRNA which can serve as a novel biomarker for diagnosis of gastric cancer. We have also provided attributes for these genes and miRNAs like pubmed id, location, chromosome number, mechanism of related gene or miRNA, transcription factors associated, technique used for the identification, reported in body fluid etc. These attributes will help in prioritizing and systematic testing of candidate biomarkers. We have constructed an integrated database with user friendly interface named as Gastric Cancer Database (GCDB). In addition, database provides various browse and search options for user to extraction or exploration of relevant information for all experimentally determined genes and miRNAs present in the database.