To Study the Diabetes Mediated CNS Complications in Mouse Model of Diabetes Mellitus II

Abstract

Diabetes Mellitus (DM) is the chronic metabolic disorder in which is characterized by persistently elevated level of blood glucose due to either insufficient production of insulin or due to insulin resistance. It is considered as most common endocrine disorder from which millions of people are affected. In 2015, 482 million people were diagnosed with DM out of which 5 million lost their life. India is home to 69.2 million diabetic people and globally stands second after China in terms of diabetic burden. Global diabetic burden is expected to up by 54% to 642 million by year 2040, in which India is projected to share 123.5 million patients. Apart from this, few other statists will clearly indicates that DM will become epidemic in coming years is that in 2015 WHO reported that 52% cases of DM remain undiagnosed, 382 million people are suffering from impaired glucose tolerance (prediabetic) and in India 21.4% population is overweight, 4.7% is obese and 12.1% population in physically inactive. All these factors are key elements for development of DM and will intensify diabetic load in near future. In terms of annual health care expenditure, 12% of global health care expenditure is spent on diabetes and despite of that we are unable to halt the development and progression of DM and its associated complications (International Diabetic Atlas, 2015). DM can be classified into 3 major catagories: