Understanding the Role of Specific Micrornas in Psoriasis Patients, With an Immunological Perspective

Abstract

INTRODUCTION Psoriasis is a chronic immune – mediated inflammatory skin disease with itchy and painful skin manifestations. Despite the efforts of IFPA (International federation of psoriasis association) and national psoriasis organizations, psoriasis continues to be a serious disease worldwide affecting over 125 million people, or nearly three percent of the world's population (National Psoriasis Foundation). Psoriasis continues to be a problem – first, because it is often misdiagnosed with other similar diseases with no standard differential diagnosis , – second, because there is a severe lack of recognition and awareness, a lack of understanding the nature of the disease both by the patient and the public (www.ifpa-pso.org) and – third, most importantly because there is no known cure as available treatment such as corticosteroids and immunosuppressants help in transient symptomatic relief with potential side effects and large number of non- responders. and not a single treatment works for everyone.