Elucidation of Genes Responsible for Quorum Sensing in Cronobacter Sakazakii

Abstract

Quorum sensing (QS) is a mechanism which enables microorganism to communicate through chemical hormone-like molecules known as auto-inducers. The external degree of the auto-inducers enhances as a characteristic of growing cellular population. The bacteria detect and respond to the signal, when an auto-inducer concentration reaches a critical threshold. Bacteria use QS to regulate a variety of phenotypes, such as motility, virulence factor production, toxin production, exopolysaccharide production, and biofilm formation, which are essential to build a successful establishment of a symbiotic or pathogenic relationship with their respective eukaryotic hosts. QS changed into first described in the mechanism liable for regulation of bioluminescence in Vibrio fischeri and Vibrio harveyi[1], and when you consider that then shown to be a considerable mechanism of gene regulation in microorganism. One of the main reasons behind people who are affected with cystic fibrosis is QS in Pseudomonas aeruginosa. Pseudomonas aeruginosa genome sequence is available in the public domain. QS mechanism in Pseudomonas aeruginosa also deals with the expression of various virulence factors