Please use this identifier to cite or link to this item: http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/5125
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dc.contributor.authorVerma, Anamika-
dc.contributor.authorShrivastava, Rahul [Guided by]-
dc.date.accessioned2022-07-25T04:31:49Z-
dc.date.available2022-07-25T04:31:49Z-
dc.date.issued2021-
dc.identifier.urihttp://ir.juit.ac.in:8080/jspui//xmlui/handle/123456789/5125-
dc.description.abstractSessile cells secrete extracellular polymeric substance (EPS) comprising of polysaccharides, proteins, lipids and eDNA which forms the matrix in which cells are embedded and held together, forming a biofilm. The EPS acts as a barrier and is necessary for biofilm survival. In nature, more than 90% bacteria live and grow in biofilms. Surface attachment, microcolony formation, maturation and dispersal are general steps of biofilm formation. Phenotypic shift from planktonic (free living) cells to sessile (surface attached) cells is mediated via changes in genetic expression through quorum sensing and cGMP mediated pathway. Pathogenic biofilms in human health cause tenacious clinical problems from non-healing chronic wounds to lung cystic fibrosis. Hospital acquired infections (HAI) are a major set back in health care industry and biofilms are the root cause. They from on the surfaces of medical devices and implants infecting various patients worldwide. Dynamic and ever evolving nature of biofilm makes it difficult to diagnose and treat infections. Therefore, better and advanced diagnostic tools like transcriptomic and wound bed analysis is required to effectively target biofilms.en_US
dc.language.isoenen_US
dc.publisherJaypee University of Information Technology, Solan, H.P.en_US
dc.subjectBiofilmsen_US
dc.subjectHospital acquired infectionsen_US
dc.subjectChronic infectionsen_US
dc.subjectBiofilm toleranceen_US
dc.titleBiofilm and Hospital Acquired Infection Mechanism, Tolerance and Treatmenten_US
dc.typeProject Reporten_US
Appears in Collections:Dissertations (M.Sc.)

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