Acoustical Studies of Drug Combiflam in Aqueous Alcoholic Mixtures

Abstract

Ultrasonic velocity measurements were carried out at frequency 1 MHz using interferometer (Mittal enterprises, New Delhi). Solvent system having 100 to 0 mol% of water with methanol (MeOH) and ethanol (EtOH) at 10 mol% intervals have been prepared and investigated. Solutions containing a Ultrasonic velocity and density measurements have been measured for drug Combiflam in binary aqueous alcoholic ( Methanol and Ethanol) mixtures at 250C. The velocity and density data of solvent/solvent mixtures/ drug solutions have been employed to calculate various desired acoustical parameters e.g. specific acoustic impedence (Z), relative association (R.A.), adiabatic compressibility (β), intermolecular free length ( Lf), molar volume (Vm) and molar sound velocity (Rm) The results of the desired parameters have been discussed as a function of solvent mixtures, concentration of drug and nature of alcohol. However, these acoustical parameters are examined in terms of drug-drug, drug-solvent and drug-surfactant interactions resulting from various electrostatic and hydrophobic interactions.