To Increase the Efficacy of Vitamin D2 on Cell Lines by Using Cissus Quadrangularis

Abstract

Vitamin D deficiency remains a global public health issue. The major function of vitamin D in vertebrates is maintenance of calcium homeostasis, but vitamin D insufficiency has also been linked to an increased risk of hypertension, autoimmune diseases, diabetes, and cancer. Natural sources of vitamin D (dietary and UVB exposure) are limited, and thus mechanisms are needed to allow individuals to achieve the new dietary recommendations. The two forms of vitamin D are ergocalciferol (vitamin D 2) synthesized by exposure of ergosterol in plants to UVB radiation and cholecalciferol (vitamin D 3) synthesized in the skin of human by UVB radiation. However, the efficacy of vitamin D2 is less as compared to Vitamin D3. As Vitamin D3 is derived from animal-based sources, vegans and vegetarians may not prefer animal sourced supplements. For this reason, D2 derived from plant-based sources is a good choice for them. Cissus quadrangularis plant have been used to cure osteoporosis and, in some studies, they have been showed that when used in combination with Vitamin D3, it increases the efficacy of it. So, in this study by using extract of this plant attempt has been made to increase the efficacy of Vitamin D2.