Assessment of Genes Involved in the Transition of Conidia to Mycelia in Aspergillus Flavus

Abstract

Aspergillus flavus is a widely known species of Aspergillus, known to produce carcinogenic Aflatoxin. It is the major cause of aflatoxicosis in humans and animals. It is mostly present in Environment due to small asexual bodies known as Conidia. The transition of Conidia to Mycelium/hyphae is the key event in the A. flavus life-cycle, which needs further exploration to identify stage-specific genes, Candidate genes, or genes involved in the production of toxins (Aflatoxin, mycotoxin, etc.). Prodigious studies have been conducted on A. flavus transition from 0 hours- 72 hours, which includes both transcriptomics and genomics approaches. However, there is a huge research gap for transcripts involved in morphogenesis at the genomics level to identify major gene clusters involved in isotropic and polarized growth. Thus, in our current study objective analysis of the transcriptome of A. flavus at 0h,5h,10h,24h, and 72h shows dormant conidia, active conidia, swollen conidia, germ tube stage, hyphae, and mycelia.