Testing the Efficacy of Gold Nanoparticles Synthesised Using Withania Somnifera against Mycobacterium Smegmatis Biofilms

Abstract

Drug resistant bacteria pose a pronounced effect on public health globally. Biofilm are associated with numerous persistent infections making them resistant towards antibiotics. Formation of Biofilm by pathogenic bacteria provides supplementary challenge for their treatment. Green synthesis of nanoparticles using plant extracts involves use of bio molecules found in them to reduce the metallic ions in nano material. Plant based green synthesis has provided marvellous advantages over physical or chemical methods of synthesis of nanoparticles. Plant based green synthesis have demonstrated other well known biological properties such as antimicrobial, anti-inflammatory, antioxidant, anticancer, anti aging and wound healing effects. Gold nanoparticles has acquired more emphasize because of their biocompatible nature, optical properties and surface functionalization. In this study, we have focused on antibiofilm activity of plant mediated synthesis of gold nanoparticles against Mycobacterium smegmatis.