Studies on DNA Repair Mechanism and Non- Small Cell Lung Cancer

Abstract

Human beings are exposed to a variety of DNA damaging compounds on a regular basis, which can have an impact on their health and affect disease states. On the other hand, DNA repair systems consistently protect DNA either by eliminating or by accepting the harm done to ensure a general survival. It is recognized that deviations from this fine-tuning can cause cellular metabolic equilibrium to become unstable. This is seen in a variety of tumours where disruption or dysregulation the DNA repair pathways leads to genomic instability. Testing for genotoxicity and controlling the use of commonly used physical, biological and chemical agents have become crucial as they have an influence on human health. In this work, we will outline DNA damage processes and the mechanisms that counteract them in order to shed light on the molecular underpinnings of genotoxicity within cell and establish the groundwork for the other articles in the issue.