Sequence Analysis for SNP Detection and Phylogenetic Reconstruction of SARS-CoV-2 Sequences Isolated from Different COVID-19 Sequences

Abstract

The brand-new coronavirus SARS-CoV-2 is what caused the COVID-19 pandemic. SARS-CoV-2 accesses host cells via the Angiotensin-converting enzyme 2 (ACE2), which is also a functional receptor on cell surfaces. ACE2 is abundantly expressed in the heart, kidneys, and lungs and is released into the plasma. The rennin angiotensin aldosterone system's main regulator is ACE2 (RAAS). Specifically in individuals with comorbidities such hypertension, Diabetes mellitus, and cardiovascular illness, SARS-CoV-2 promotes ACE/ACE2 balance disturbance and RAAS activation, which ultimately leads to COVID-19 development. As a Result, ACE2 expression may have contradictory effects, promoting SARS-CoV-2 pathogenicity while inhibiting viral infection.