Structural, Functional, and Evolutionary Level Mutational Analysis of Trem2 Gene to Study Its Role in Alzheimer’s Disease

Please use this identifier to cite or link to this item: http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/10270

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DC Field	Value	Language
dc.contributor.author	Ajay Kumar	-
dc.contributor.author	Singh, Tiratha Raj [Guided by]	-
dc.date.accessioned	2023-10-30T04:54:28Z	-
dc.date.available	2023-10-30T04:54:28Z	-
dc.date.issued	2022	-
dc.identifier.uri	http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/10270	-
dc.description	Enrollment No. 207803	en_US
dc.description.abstract	The TREM 2 gene present in the myeloid cell increases the risk of Alzheimer’s disease (AD) in an individual. TREM 2 cells can be associated with the cause of inflammation and immune disorder which is a major cause of AD. Single-nucleotide polymorphisms (SNPs) associated with complex diseases can originate, remove, or change protein coding sites. TREM2 stands for Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that regulates the activity and survival of microglia. Some of the rare variants are associated with an increased risk of AD related to TREM2. A systematic in-silico investigation of disease-associated nsSNPs in human TREM2 was performed in this study.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Jaypee University of Information Technology, Solan, H.P.	en_US
dc.subject	Alzheimer’s Disease	en_US
dc.subject	Inflammation	en_US
dc.subject	Immune disorder	en_US
dc.subject	Single-nucleotide polymorphisms	en_US
dc.title	Structural, Functional, and Evolutionary Level Mutational Analysis of Trem2 Gene to Study Its Role in Alzheimer’s Disease	en_US
dc.type	Dissertation	en_US
Appears in Collections:	Dissertations (M.Sc.)

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