Structural, Functional, and Evolutionary Level Mutational Analysis of Trem2 Gene to Study Its Role in Alzheimer’s Disease

Abstract

The TREM 2 gene present in the myeloid cell increases the risk of Alzheimer’s disease (AD) in an individual. TREM 2 cells can be associated with the cause of inflammation and immune disorder which is a major cause of AD. Single-nucleotide polymorphisms (SNPs) associated with complex diseases can originate, remove, or change protein coding sites. TREM2 stands for Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that regulates the activity and survival of microglia. Some of the rare variants are associated with an increased risk of AD related to TREM2. A systematic in-silico investigation of disease-associated nsSNPs in human TREM2 was performed in this study.